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| 货号 | RC0271 |
| 名称 | 犬尿喹酸（4-羟基喹啉-2-甲酸,Kynurenic Acid） |
| 说明书 | |
| CAS号 | 492-27-3 |
| 分子式 | C10H7NO3 |
| 分子量 | 189.17 |
| 产品描述 | |
| 描述 | Kynurenic acid is a metabolite of tryptophan in mammals via the kynurenine pathway. Studies have observed that Kynurenic acid acts as a ligand to the GPR35 G protein-coupled receptor. The binding of Kynurenic acid to GPR35 has been noted to affect calcium mobilization and inositol phosphatase synthesis and may indicate potential signaling functions by Kynurenic acid via the GPR35 receptor. Additionally reported to be a broad spectrum, excitatory amino acid (EAA) antagonist. Other studies have reported that Kynurenic acid acts as an antagonist to mammalian ionotropic glutamate receptors especially NMDA (N-methyl-D-aspartate receptors).Kynurenic acid is an inhibitor of AChR α7, GluR and GlyR. |
| Also available as a Kynurenic acid, sodium salt | |
| 应用 | An antagonist of NMDA and AMPA/kainate receptors |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at 4° C |
| 形态 | Solid |
| 基本信息 | |
| 别名 | 4-羟基喹啉-2-甲酸 |
| 外观 | Powder |
| 密度 | 1.43 g/cm3 (Predicted) |
| 熔点 | 275° C (lit.)(dec.) |
| 沸点 | 358.36° C at 760 mmHg (Predicted) |
| 折射率 | n20D 1.64 (Predicted) |
| PK值 | pKa: 3.49 (Predicted), pKb: 0.36 (Predicted) |
| Ki 数据 | Glutamate (NMDA) receptor subunit zeta 1: Ki= 5.4 µM (rat); Vesicular glutamate transporter 3: Ki= 1.3 mM (rat) |
| 可溶性/溶解性 | Soluble in water (partly), hot alcohol, DMSO (75 mM), 0.1 M NaOH (50 mg/ml), and methanol. |
| MDL | MFCD00006753 |
| PubChem CID | 3845 |
| Beilstein 注册 | 147451 |
| EC号码 | 207-751-5 |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 | |
